A college student collapses after rowdy sex with his girlfriend. While House and his team attempt to determine the cause, the student's condition continues to deteriorate and his symptoms multiply complicating the diagnosis.
A nun whose hands are red, swollen and cracked is sent to House. The nun believes it is stigmata, but House suspects an allergic reaction. He gives her some pills, which cause her to become unable to breathe. As her condition worsens, her fellow sisters pray for her while House and his team work to discover the cause of her illness while House has to wonder if he misadministered the illness.
A Kindergarten teacher starts speaking gibberish and passed out in front of her class. What looks like a possible brain tumor does not respond to treatment and provides many more questions than answers for House and his team as they engage in a risky trial-and-error approach to her case. When the young teacher refuses any additional variations of treatment and her life starts slipping away, House must act against his code of conduct and make a personal visit to his patient to convince her to trust him one last time.
When a teenage lacrosse player is stricken with an unidentifiable brain disease, Dr. House and the team hustle to give his parents answers. Chase breaks the bad news, the kid has MS, but the boy's night-terror hallucinations disprove the diagnosis and send House and his team back to square one. As the boy's health deteriorates. House's side-bet on the paternity of the patient infuriates Dr. Cuddy and the teenager's parents, but may just pay off in spades.
This episode included 4 minutes of scenes which were edited out from the version that aired on November 16, 2004. It was released in limited number in magazines, etc. to introduce the program to the viewing audience. A web site was set up by FOX so that viewers could log on and give their opinions of the program.
House and the team take on the case of a 22-year-old minor league hockey player who collapsed while coughing up blood after a fight on the ice. Meanwhile, House drops a bomb on Wilson, and Chase offers to help Park change her living arrangement.